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2005 1
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2008 6
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115 results

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Adiponectin/AdiopR1 signaling prevents mitochondrial dysfunction and oxidative injury after traumatic brain injury in a SIRT3 dependent manner.
Zhang S, Wu X, Wang J, Shi Y, Hu Q, Cui W, Bai H, Zhou J, Du Y, Han L, Li L, Feng D, Ge S, Qu Y. Zhang S, et al. Redox Biol. 2022 Aug;54:102390. doi: 10.1016/j.redox.2022.102390. Epub 2022 Jun 30. Redox Biol. 2022. PMID: 35793583 Free PMC article.
These effects were significantly alleviated after APN receptor agonist (AdipoRon) treatment. Moreover, we found that AdipoR1, rather than AdipoR2, mediated the protective effects of APN/AdipoR signaling against oxidative stress and brain injury after TBI. In neuron- …
These effects were significantly alleviated after APN receptor agonist (AdipoRon) treatment. Moreover, we found that AdipoR1, rather …
Adiponectin suppresses amyloid-beta oligomer (AbetaO)-induced inflammatory response of microglia via AdipoR1-AMPK-NF-kappaB signaling pathway.
Jian M, Kwan JS, Bunting M, Ng RC, Chan KH. Jian M, et al. J Neuroinflammation. 2019 May 25;16(1):110. doi: 10.1186/s12974-019-1492-6. J Neuroinflammation. 2019. PMID: 31128596 Free PMC article.
Adiponectin (APN), an adipocyte-derived adipokine, exerts anti-inflammatory effects in the periphery and brain. Chronic APN deficiency leads to cognitive impairment and AD-like pathologies in aged mice. ...Compound C, an inhibitor of AMPK, abolished these effects of APN. K …
Adiponectin (APN), an adipocyte-derived adipokine, exerts anti-inflammatory effects in the periphery and brain. Chronic APN deficienc …
Adiponectin and Cognitive Decline.
Rizzo MR, Fasano R, Paolisso G. Rizzo MR, et al. Int J Mol Sci. 2020 Mar 16;21(6):2010. doi: 10.3390/ijms21062010. Int J Mol Sci. 2020. PMID: 32188008 Free PMC article. Review.
Later, ADPN receptors were also found in the central nervous system (CNS). In fact, the receptors AdipoR1 and AdipoR2 are expressed in various areas of the brain, including the hypothalamus, hippocampus, and cortex. ...Based on this, it is of great interest to inves …
Later, ADPN receptors were also found in the central nervous system (CNS). In fact, the receptors AdipoR1 and AdipoR2 are expressed i …
Expression and localization of adiponectin and its receptors (AdipoR1 and AdipoR2) in the hypothalamic-pituitary-ovarian axis of laying hens.
Li C, Li Q, Li J, Zhang N, Li Y, Li Y, Li H, Yan F, Kang X, Liu X, Li K, Tian Y. Li C, et al. Theriogenology. 2021 Jan 1;159:35-44. doi: 10.1016/j.theriogenology.2020.10.020. Epub 2020 Oct 13. Theriogenology. 2021. PMID: 33113442
The results showed that adiponectin mRNA and protein were widely expressed in all tissues involved in the HPO axis in laying hens, with especially high expression in the hypothalamus. Both AdipoR1 and AdipoR2 were more highly expressed in the pituitary than in other tissue …
The results showed that adiponectin mRNA and protein were widely expressed in all tissues involved in the HPO axis in laying hens, with espe …
Running exercise alleviates hippocampal neuroinflammation and shifts the balance of microglial M1/M2 polarization through adiponectin/AdipoR1 pathway activation in mice exposed to chronic unpredictable stress.
Liu L, Tang J, Liang X, Li Y, Zhu P, Zhou M, Qin L, Deng Y, Li J, Wang Y, Jiang L, Huang D, Zhou Y, Wang S, Xiao Q, Luo Y, Tang Y. Liu L, et al. Mol Psychiatry. 2024 Feb 15. doi: 10.1038/s41380-024-02464-1. Online ahead of print. Mol Psychiatry. 2024. PMID: 38361125
Running exercise increases circulating levels of adiponectin which is known to cross the blood-brain barrier and suppress inflammatory responses. AdipoR1 is an adiponectin receptor that is involved in regulating microglial phenotypes and activation states. ...These …
Running exercise increases circulating levels of adiponectin which is known to cross the blood-brain barrier and suppress inflammator …
Adiponectin controls the apoptosis and the expression of tight junction proteins in brain endothelial cells through AdipoR1 under beta amyloid toxicity.
Song J, Choi SM, Whitcomb DJ, Kim BC. Song J, et al. Cell Death Dis. 2017 Oct 12;8(10):e3102. doi: 10.1038/cddis.2017.491. Cell Death Dis. 2017. PMID: 29022894 Free PMC article.
Alzheimer's disease (AD) is the most common neurodegenerative disease, characterized by excessive beta amyloid (Abeta) deposition in brain, leading to blood-brain barrier (BBB) disruption. The mechanisms of BBB disruption in AD are still unclear, despite considerabl …
Alzheimer's disease (AD) is the most common neurodegenerative disease, characterized by excessive beta amyloid (Abeta) deposition in brai …
Sex differences in hearing impairment due to diet-induced obesity in CBA/Ca mice.
Kim SJ, Gajbhiye A, Lyu AR, Kim TH, Shin SA, Kwon HC, Park YH, Park MJ. Kim SJ, et al. Biol Sex Differ. 2023 Feb 21;14(1):10. doi: 10.1186/s13293-023-00493-z. Biol Sex Differ. 2023. PMID: 36810096 Free PMC article.
The serum concentration of adiponectin, an otoprotective adipokine, was significantly higher in female than in male mice; cochlear adiponectin levels were elevated by HFD in female but not male mice. Adiponectin receptor 1 (AdipoR1) was widely expressed in the inner ear, a …
The serum concentration of adiponectin, an otoprotective adipokine, was significantly higher in female than in male mice; cochlear adiponect …
ADIPOR1 is essential for vision and its RPE expression is lost in the Mfrp(rd6) mouse.
Sluch VM, Banks A, Li H, Crowley MA, Davis V, Xiang C, Yang J, Demirs JT, Vrouvlianis J, Leehy B, Hanks S, Hyman AM, Aranda J, Chang B, Bigelow CE, Rice DS. Sluch VM, et al. Sci Rep. 2018 Sep 25;8(1):14339. doi: 10.1038/s41598-018-32579-9. Sci Rep. 2018. PMID: 30254279 Free PMC article.
The knockout (KO) of the adiponectin receptor 1 (AdipoR1) gene causes retinal degeneration. Here we report that ADIPOR1 protein is primarily found in the eye and brain with little expression in other tissues. ...This dysregulation of IRBP hypothesizes a role …
The knockout (KO) of the adiponectin receptor 1 (AdipoR1) gene causes retinal degeneration. Here we report that ADIPOR1 protei …
Adiponectin: an update.
Guerre-Millo M. Guerre-Millo M. Diabetes Metab. 2008 Feb;34(1):12-8. doi: 10.1016/j.diabet.2007.08.002. Diabetes Metab. 2008. PMID: 18069030 Review.
Adipose cells produce both proteins and release them into the circulation. Leptin acts as a fundamental signal for the brain to modulate food intake as a function of energy status. Loss of leptin function results in obesity. ...Adiponectin signaling pathways comprise at le …
Adipose cells produce both proteins and release them into the circulation. Leptin acts as a fundamental signal for the brain to modul …
Adiponectin Ameliorates GMH-Induced Brain Injury by Regulating Microglia M1/M2 Polarization Via AdipoR1/APPL1/AMPK/PPARgamma Signaling Pathway in Neonatal Rats.
Xu N, Li X, Weng J, Wei C, He Z, Doycheva DM, Lenahan C, Tang W, Zhou J, Liu Y, Xu Q, Liu Y, He X, Tang J, Zhang JH, Duan C. Xu N, et al. Front Immunol. 2022 Jun 3;13:873382. doi: 10.3389/fimmu.2022.873382. eCollection 2022. Front Immunol. 2022. PMID: 35720361 Free PMC article.
To further explore the underlying mechanisms of these effects, we found that the expression of Adiponectin receptor 1 (AdipoR1) primarily colocalized with microglia and neurons in the brain. ...In all, we propose that APN works as a potential therapeutic agent to am …
To further explore the underlying mechanisms of these effects, we found that the expression of Adiponectin receptor 1 (AdipoR1) prima …
115 results